“A human being is defeated in all his activities as long as he does not know the goal of life, which can be understood when one is inquisitive about Brahman.” It is such inquiry that begins the Vedānta-sūtra: athāto brahma-jijñāsā. A human being should be inquisitive to know who he is, what the universe is, what God is, and what the relationship is between himself, God and the material world. Such questions cannot be asked by cats and dogs, but they must arise in the heart of a real human being. Knowledge of these four items – namely, oneself, the universe, God, and their internal relationship-is called sambandha-jñāna, or the knowledge of one’s relationship. When one’s relationship with the Supreme Lord is established, the next program is to act in that relationship. This is called abhidheya, or activity in relationship with the Lord. After executing such prescribed duties, when one attains the highest goal of life, love of Godhead, he achieves prayojana-siddhi or the fulfillment of his human mission.
Ref >> Srila Prabhupada Vani.